MR Spectroscopy of GABA and Other Brain Metabolites in Smelters Exposed to Manganese

نویسندگان

  • U. Dydak
  • L. Long
  • H. Zhu
  • W. Li
  • Y. Jiang
  • J. Chen
  • X. Fu
  • S. Hu
  • R. A. Edden
  • D. Meier
  • M. Aschner
  • J. Murdoch
  • W. Zheng
چکیده

U. Dydak, L. Long, H. Zhu, W. Li, Y. Jiang, J. Chen, X. Fu, S. Hu, R. A. Edden, D. Meier, M. Aschner, J. Murdoch, and W. Zheng School of Health Sciences, Purdue University, West Lafayette, IN, United States, Dep. of Radiology, Indiana University School of Medicine, Indianapolis, IN, United States, Dep. of Radiology, Guangxi Medical University, Nanning, China, People's Republic of, Dep. of Radiology, Johns Hopkins University, Baltimore, MD, United States, Dep. of Occup. Health and Toxicology, Guangxi Medical University, Nanning, China, People's Republic of, Guizhou Inst. of Occup. Safety and Health, Zunyi, China, People's Republic of, Philips Healthcare, China, People's Republic of, Schools of Biosciences and Chemistry, Cardiff University, United Kingdom, Inst. for Biomed. Engineering, ETH and University Zuerich, Switzerland, Dep. of Pediatrics, Vanderbilt University, Nashville, TN, United States, Philips Healthcare, Cleveland, OH, United States

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

In Vivo Measurement of Brain GABA Concentrations by Magnetic Resonance Spectroscopy in Smelters Occupationally Exposed to Manganese

BACKGROUND Exposure to excessive levels of manganese (Mn) is known to induce psychiatric and motor disorders, including parkinsonian symptoms. Therefore, finding a reliable means for early detection of Mn neurotoxicity is desirable. OBJECTIVES Our goal was to determine whether in vivo brain levels of γ-aminobutyric acid (GABA), N-acetylaspartate (NAA), and other brain metabolites in male smel...

متن کامل

نسبت منگنز به آهن خون (Manganese-Iron Ratio: MIR) به عنوان یک بیومارکر بالقوه در ارزیابی مواجهه شغلی با منگنز

Background and aims: Biological monitoring plays an important role in occupational exposure assessment. The aim of present study was to assess Manganese-Iron Ratio (MIR) as a potential biomarker for manganese. Methods: This cross-sectional study was carried out in an automotive parts manufacturing industry in Tehran, Iran. 31 ferroalloy smelters as exposed group (cases) and 30 office workers...

متن کامل

Vulnerability of welders to manganese exposure--a neuroimaging study.

Increased manganese (Mn) exposure is known to cause cognitive, psychiatric and motor deficits. Mn exposure occurs in different occupational settings, where the airborne Mn level and the size of respirable particulates may vary considerably. Recently the importance of the role of the cerebral cortex in Mn toxicity has been highlighted, especially in Mn-induced neuropsychological effects. In this...

متن کامل

High-resolution GABA detection with/without J decoupling using 2D multiple-quantum coherence spectroscopy

Introduction Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in mammalian and human brains. Noninvasive detection of GABA has been of interest in the study of neurological and psychiatric disorders. Proton MR spectroscopy (MRS) offers an useful tool for noninvasively measurement of GABA concentrations in human and animal brains. However, the narrow chemical shift dispersi...

متن کامل

Relations of biomarkers of manganese exposure and neuropsychological effects among welders and ferroalloy smelters

The objective of present study was to assess relationship between biomarkers of Manganese (Mn) and neuropsychological effects. The study was carried out on 27 welders and 31 ferroalloy smelters as Mn-exposed groups and 30 office workers as unexposed controls. Air Mn concentrations were determined according to NIOSH method 7300. The biological samples were prepared using microwave assisted acid ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2008