MR Spectroscopy of GABA and Other Brain Metabolites in Smelters Exposed to Manganese
نویسندگان
چکیده
U. Dydak, L. Long, H. Zhu, W. Li, Y. Jiang, J. Chen, X. Fu, S. Hu, R. A. Edden, D. Meier, M. Aschner, J. Murdoch, and W. Zheng School of Health Sciences, Purdue University, West Lafayette, IN, United States, Dep. of Radiology, Indiana University School of Medicine, Indianapolis, IN, United States, Dep. of Radiology, Guangxi Medical University, Nanning, China, People's Republic of, Dep. of Radiology, Johns Hopkins University, Baltimore, MD, United States, Dep. of Occup. Health and Toxicology, Guangxi Medical University, Nanning, China, People's Republic of, Guizhou Inst. of Occup. Safety and Health, Zunyi, China, People's Republic of, Philips Healthcare, China, People's Republic of, Schools of Biosciences and Chemistry, Cardiff University, United Kingdom, Inst. for Biomed. Engineering, ETH and University Zuerich, Switzerland, Dep. of Pediatrics, Vanderbilt University, Nashville, TN, United States, Philips Healthcare, Cleveland, OH, United States
منابع مشابه
In Vivo Measurement of Brain GABA Concentrations by Magnetic Resonance Spectroscopy in Smelters Occupationally Exposed to Manganese
BACKGROUND Exposure to excessive levels of manganese (Mn) is known to induce psychiatric and motor disorders, including parkinsonian symptoms. Therefore, finding a reliable means for early detection of Mn neurotoxicity is desirable. OBJECTIVES Our goal was to determine whether in vivo brain levels of γ-aminobutyric acid (GABA), N-acetylaspartate (NAA), and other brain metabolites in male smel...
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Background and aims: Biological monitoring plays an important role in occupational exposure assessment. The aim of present study was to assess Manganese-Iron Ratio (MIR) as a potential biomarker for manganese. Methods: This cross-sectional study was carried out in an automotive parts manufacturing industry in Tehran, Iran. 31 ferroalloy smelters as exposed group (cases) and 30 office workers...
متن کاملVulnerability of welders to manganese exposure--a neuroimaging study.
Increased manganese (Mn) exposure is known to cause cognitive, psychiatric and motor deficits. Mn exposure occurs in different occupational settings, where the airborne Mn level and the size of respirable particulates may vary considerably. Recently the importance of the role of the cerebral cortex in Mn toxicity has been highlighted, especially in Mn-induced neuropsychological effects. In this...
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Introduction Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in mammalian and human brains. Noninvasive detection of GABA has been of interest in the study of neurological and psychiatric disorders. Proton MR spectroscopy (MRS) offers an useful tool for noninvasively measurement of GABA concentrations in human and animal brains. However, the narrow chemical shift dispersi...
متن کاملRelations of biomarkers of manganese exposure and neuropsychological effects among welders and ferroalloy smelters
The objective of present study was to assess relationship between biomarkers of Manganese (Mn) and neuropsychological effects. The study was carried out on 27 welders and 31 ferroalloy smelters as Mn-exposed groups and 30 office workers as unexposed controls. Air Mn concentrations were determined according to NIOSH method 7300. The biological samples were prepared using microwave assisted acid ...
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